Since opening, the gallery has presented to the work of many leading international artists including Matthew Barney, Gerard Byrne, Dorothy Cross, Nancy Holt, Josephsohn, Richard Long, Eva Rothschild, Danh Vo and Ai Weiwei.
In 2011 a second project space, St Carthage Hall, located in the town of Lismore opened. This gallery, in a former church, has presented a varied programme of exhibitions including works by Camille Henrot, Martin Healy, Niamh O'Malley, Roman Signer, Superflex and Corban Walker.
A third space - The Mill - opened in 2022 on the outskirts of Lismore town, bringing back into use a historically significant building, and allowing an opportunity to present more physically challenging artworks. In 2022 the space hosted Cascade by Virginia Overton.
Lismore Castle Arts is situated in the historic gardens of Lismore Castle, which includes permanent works by Roger Hiorns, Eilís O'Connell and Franz West. Lismore Castle Arts has a deeply embedded community engagement programme, with learning projects such as Artifice, and projects such as A Space for Lismore, which foster long term projects between artists and communities.
Lismore Castle Arts' exhibition programme is kindly funded by the Arts Council, and Waterford City & County Council Arts Grant.